Unexpected associations found between drug response and cell changes in brain cancer

Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways. These are the conclusions from a study from Uppsala University investigating a large number of cell samples from patients with brain tumours. The researchers have characterised how changes in glioblastoma cells influence the effect of different drugs. Their findings are published in the journal Cell Reports.

Most of the glioblastoma cells in the study are from the Human Glioma Cell Culture (HGCC) biobank, founded and run by Uppsala University researchers, many of whom are involved in the present study. HGCC consists of cell cultures grown from cells taken from brain tumour patients in operations.

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