UK Biobank cohort to Predict Pancreatic Cancer

An association between diabetes mellitus (DM), especially, new-onset DM (NODM), and pancreatic ductal adenocarcinoma (PDAC) is known; others have constructed polygenic risk scores (PRS) related to PDAC risk. An independent cohort was used to compare the performance of these PRS in order to ascertain whether they can distinguish between NODM and long-standing DM (LSDM) patients suffering from PDAC.

The UK Biobank was used to select cases (1,042) and matched cancer-free controls (10,420). It was concluded that PDAC related common genetic variants are more strongly associated with DM.

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