Rapid establishment of a COVID-19 perinatal biorepository

The establishment of a COVID-19 biorepository of specimens from the maternal-neonatal dyad is a critical first step to answering questions about the impact of COVID-19 infection on the pregnant patient and the developing fetus. The key questions include, among others:

  1. How does pregnancy impact the immune response to COVID-19?
  2. What are the mechanisms underlying severe maternal morbidity?
  3. Does the vertical transmission of the virus occur? If so, how?
  4. Is breastfeeding safe and does it provide protection for the neonate?
  5. What is the impact of the maternal immune response to COVID-19 on the developing fetus?


Samples collected on maternal and newborn participants

Establishing a COVID-19 perinatal biorepository required patient advocacy, transdisciplinary collaboration, and creative solutions to unique challenges. This biorepository is unique in its comprehensive sample collection and the inclusion of a control population. It serves as an important resource for research into the impact of COVID-19 on pregnant women and newborns and provides lessons for future biorepository efforts.

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