Abstract: Gynecological tissue biobanks play a pivotal role in advancing oncologic research by integrating clinical, molecular, and longitudinal biospecimen data. These biobanks address the broad heterogeneity of gynecologic malignancies, which include common and rare diseases with distinct molecular subtypes. Specimen acquisition extends beyond traditional tissues to include cervicovaginal microbiomes and ascitic fluid, requiring tailored collection strategies and dedicated repositories. The use of high-quality biospecimen annotation and multi-omics approaches enhances translational research but also introduces challenges in managing complex, high-dimensional datasets.
Collaborative biobank networks and robust governance frameworks are essential for ethical oversight, data sharing, and addressing cultural sensitivities related to female fertility and familial disease risk. Emerging technologies such as spatial biology and liquid biopsies complement classical specimen collection methods and should be integrated into standardized protocols. Overall, gynecological tissue biobanks represent a complex yet indispensable resource that demands innovative strategies for ethical management and scientific advancement.
Read more about this development here: Biobanking and gynecologic oncology – Special considerations, challenges and opportunities – ScienceDirect.