Banking primary prostate cancer is challenging because the tumors are often difficult to visualize in the gross specimens and are frequently multifocal. However, biobanking tissue of high quality and fidelity is imperative for cancer genomics research.
The researchers from Weill Cornell Medicine conducted a pilot study evaluating pathologic concordance of biobanked tissue and the radical prostatectomy specimen using either standard protocol (SP) vs. next-generation protocol (NGP). There were no significant differences in clinical and pathologic characteristics (age, BMI, preoperative PSA, prostate weight, race, final prostatectomy Gleason score, or pathologic tumor and nodal stages) between the two protocol arms.
The study validated the NGP as a multidisciplinary approach for improving the fidelity and amount of biobanked primary CaP tissue for future studies.
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